Opioids cross the placenta and could generate respiratory despair and psycho-physiologic effects in neonates. An opioid antagonist, for instance naloxone, should be obtainable for reversal of opioid-induced respiratory depression inside the neonate. DILAUDID INJECTION just isn't recommended for use in pregnant women for the duration of or immediately just before labor, when other analgesic tactics are more ideal.

Hydromorphone could improve the neuromuscular blocking action of skeletal muscle mass relaxants and develop a heightened diploma of respiratory depression.

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As a consequence of identical pharmacological Attributes, it really is sensible to count on related risk While using the concomitant utilization of other CNS depressant medication with opioid analgesics [see DRUG INTERACTIONS].

Extended utilization of DILAUDID INJECTION for the duration of pregnancy can result in neonatal opioid withdrawal syndrome, which may be lifestyle-threatening if not regarded and dealt with, and calls for management In accordance with protocols formulated by neonatology experts.

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Hydromorphone wasn't mutagenic in the in vitro bacterial reverse mutation assay (Ames assay). Hydromorphone wasn't clastogenic in possibly the in vitro human lymphocyte chromosome aberration assay or maybe the in vivo mouse micronucleus assay.

Due to the fact Many of these reactions were claimed voluntarily from the inhabitants of unsure dimension, It's not necessarily usually probable to reliably estimate their frequency or create a causal romantic relationship to drug publicity.

The causal job of opioids from the clinical syndrome of hypogonadism is not known because the several health care, Actual physical, Life style, and psychological stressors which will influence gonadal hormone degrees have not been adequately managed for in research conducted thus far [see Adverse Reactions (six)].

The concomitant utilization of anticholinergic medicine could maximize chance of urinary retention and/or intense constipation, which may lead to paralytic ileus.

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The concomitant usage of anticholinergic medications may enhance risk of urinary retention and/or severe constipation, which may bring on paralytic ileus.

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